Evidence supporting the use of: Vitamin E (delta-tocotrienol)
For the health condition: Arteriosclerosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Delta-tocotrienol is a member of the vitamin E family, distinct from tocopherols, and has drawn scientific interest for its potential cardiovascular benefits, including the treatment or prevention of arteriosclerosis (the thickening and hardening of arterial walls). Some preclinical and limited clinical studies suggest tocotrienols may exert anti-atherogenic effects due to their antioxidant, anti-inflammatory, and cholesterol-lowering properties. For instance, animal studies have demonstrated that tocotrienol supplementation can reduce plaque formation and decrease serum cholesterol levels. Small-scale human trials have reported modest improvements in lipid profiles and markers of oxidative stress, both of which contribute to arteriosclerosis. However, most human data are preliminary, with inconsistent results and limited sample sizes.

A 2015 review in Oxidative Medicine and Cellular Longevity highlights tocotrienols’ ability to inhibit HMG-CoA reductase (the enzyme targeted by statin drugs), reduce arterial stiffness, and improve endothelial function in animal models. Nonetheless, large-scale, well-controlled human clinical trials directly assessing delta-tocotrienol’s impact on arteriosclerosis endpoints remain lacking. Thus, while the mechanistic rationale is compelling and early data are promising, the current evidence base is insufficient to firmly support its clinical use for arteriosclerosis, leading to a moderate evidence rating. Further rigorous research is necessary to clarify its therapeutic role.

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