Evidence supporting the use of: Vitamin E (gamma tocopherol)
For the health condition: Arteriosclerosis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, particularly in the form of gamma-tocopherol, has been studied for its potential role in supporting cardiovascular health, including arteriosclerosis (the thickening and hardening of arterial walls). The scientific rationale is largely based on Vitamin E's antioxidant properties, which could theoretically reduce oxidative stress and prevent the oxidation of low-density lipoprotein (LDL) cholesterol—a process implicated in atherogenesis. Gamma-tocopherol, as opposed to alpha-tocopherol, is noted for its ability to trap reactive nitrogen species and may have unique anti-inflammatory effects. Some observational studies and small clinical trials have suggested that higher intakes of dietary Vitamin E are associated with a reduced risk of cardiovascular disease. However, large randomized controlled trials (RCTs) and meta-analyses have failed to demonstrate a significant benefit of Vitamin E supplementation (including gamma-tocopherol) in preventing or treating arteriosclerosis or related cardiovascular outcomes. In some cases, high-dose supplementation has even been associated with adverse outcomes.

In summary, while there is a plausible scientific basis and some early supporting evidence for the use of gamma-tocopherol in arteriosclerosis, the overall quality and consistency of evidence are low. Current guidelines do not recommend Vitamin E supplementation for the prevention or treatment of arteriosclerosis due to the lack of proven efficacy in well-conducted clinical trials.

More about Vitamin E (gamma tocopherol)
More about Arteriosclerosis

Products containing Vitamin E (gamma tocopherol)

We currently have no products on Vitabase that contain this ingredient.