Relationship: Arthritis and alpha lipoic acid

Evidence supporting the use of: Alpha lipoic acid
For the health condition: Arthritis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) is an antioxidant compound that has been studied for its potential benefits in various inflammatory and degenerative diseases, including arthritis. The use of ALA for arthritis is primarily justified by emerging scientific evidence rather than longstanding traditional use. Preclinical studies have shown that ALA can reduce markers of oxidative stress and inflammation, both of which are implicated in the pathogenesis of arthritic conditions such as rheumatoid arthritis (RA) and osteoarthritis (OA).

Some small clinical trials and animal studies suggest that ALA supplementation may help decrease levels of pro-inflammatory cytokines (such as TNF-α and IL-6) and may protect cartilage from degradation. For example, a 2021 randomized controlled trial showed mild improvements in inflammatory markers and pain scores in RA patients taking ALA as an adjunct to standard treatment. However, these studies are limited by small sample sizes, short durations, and methodological concerns, making the current evidence preliminary.

Overall, while there is some scientific rationale and early research supporting the use of ALA for arthritis, the strength of evidence is currently modest (rated 2/5). Larger, high-quality clinical trials are needed to confirm its efficacy and safety for this indication. ALA is not a mainstay treatment for arthritis, but it may be considered as a complementary therapy under medical supervision.

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adrenal cortex
alfalfa
algal oil
allspice
aloe vera
alpha-linolenic acid (ALA)
alpha-pinene
amino acids
anthocyanins
ashwagandha
astaxanthin
bamboo
barberry
basil
berry flavor
beta caryophyllene
Beta-Glucan
black cumin
black currant
black garlic
black pepper
sesame
black tea
blackberry
blueberry
borage oil
boron
Indian frankincense
bovine
bovine gelatin
broccoli
bromelain
burdock
calamari oil
cannabis sativa oil
capsaicinoids
carrot
cartilage
cat's claw
caterpillar mushroom
celery
cherry
chondroitin
chymotrypsin
cinnamon
citrus oil
clove
collagen
collard
conjugated linoleic acid (CLA)
copper
cordyceps
cowage seed
cryptoxanthin
turmeric
curcumin
devil's claw
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
evening primrose oil
fish oil
fish protein
flavonols
flaxseed
gamma linolenic acid (GLA)
gamma tocopherol
gelatin
genistein
ginger
ginseng
glucosamine
gooseberry
gotu kola
green lipped mussel
green tea
guggul
heartwood
hemp oil
horsetail
hyaluronic acid
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knotweed
kale
krill oil
kudzu
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mackerel
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marine lipid
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microbial enzymes (proprietary)
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mustard seed
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n-acetyl-cysteine (NAC)
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oleic acid
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omega-3 fatty acids
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oregon grape
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phospholipids
phytocannabinoids
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vitamin D3
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watercress
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squawvine
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Evidence supporting the use of: Alpha lipoic acid
For the health condition: Arthritis

Table of Contents

Synopsis

Other ingredients used for Arthritis

Other health conditions supported by alpha lipoic acid

Products containing alpha lipoic acid

Health Concerns

Brands

Evidence supporting the use of: Alpha lipoic acidFor the health condition: Arthritis

Table of Contents

Synopsis

Other ingredients used for Arthritis

Other health conditions supported by alpha lipoic acid

Products containing alpha lipoic acid

Evidence supporting the use of: Alpha lipoic acid
For the health condition: Arthritis