Synopsis

Source of validity: Scientific
Rating (out of 5): 2

N-acetyl-cysteine (NAC) is an antioxidant supplement that has been investigated for its potential role in supporting or treating arthritis, particularly due to its capacity to replenish intracellular glutathione and reduce oxidative stress. While there is scientific interest and some preliminary research, the evidence supporting NAC’s use for arthritis is limited and not robust. A handful of animal studies and small clinical trials suggest that NAC may help decrease inflammation and cartilage degradation in models of osteoarthritis and rheumatoid arthritis. For example, some studies have found that NAC can inhibit the production of pro-inflammatory cytokines and reduce oxidative damage in joint tissues, which are factors implicated in the pathogenesis of arthritis. However, high-quality, large-scale human clinical trials are lacking. Most of the available studies are preclinical or involve small patient populations, and results are not always consistent. Systematic reviews and meta-analyses have not established NAC as a standard or clearly effective therapy for arthritis. Current guidelines from major rheumatological societies do not recommend NAC as a treatment for arthritis. In summary, while there is some scientific rationale and preliminary evidence for the use of NAC as an adjunctive therapy in arthritis due to its antioxidant and anti-inflammatory properties, the overall quality and quantity of evidence are currently insufficient to support its routine use for this condition. More rigorous clinical research is needed to clarify its efficacy and safety in arthritis patients.

More about n-acetyl-cysteine (NAC)
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