Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl-L-Tyrosine is a modified form of the amino acid L-tyrosine, often used in dietary supplements marketed for athletic and exercise support. The rationale for its use is rooted in its role as a precursor to dopamine, norepinephrine, and epinephrine—neurotransmitters involved in alertness, focus, and the body’s stress response. During prolonged or intense exercise, levels of these neurotransmitters can decline, potentially leading to reduced performance, fatigue, and impaired cognitive function. Some studies suggest that supplementation with L-tyrosine (and by extension, acetyl-L-tyrosine, which may have better bioavailability) can help maintain cognitive performance and mood during acute physical stress, such as extended exercise or military training. However, direct evidence that acetyl-L-tyrosine specifically enhances physical athletic performance (strength, endurance, or recovery) in healthy individuals is limited and mixed. Most research has focused on cognitive or stress-related outcomes rather than direct improvements in exercise capacity. Therefore, while there is a plausible scientific basis for its use as an exercise aid—primarily targeting mental aspects such as focus and resilience to stress—the overall evidence supporting significant athletic benefits is modest, meriting a rating of 2 out of 5.

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