Evidence supporting the use of: Agmatine
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Agmatine is a naturally occurring derivative of the amino acid arginine and has garnered interest as a dietary supplement, including for athletic and exercise-related purposes. The rationale for its use is primarily based on its purported roles in neurotransmitter modulation, nitric oxide synthesis, and potential ergogenic effects. Some proponents suggest that agmatine may enhance exercise performance by improving blood flow (via modulation of nitric oxide pathways), reducing pain perception, and supporting recovery due to its neuroprotective and anti-inflammatory properties.
However, the direct scientific evidence supporting agmatine as an effective athletic or exercise aid in humans is limited. Most of the research to date has been conducted in animal models or in vitro, where agmatine has shown some promise in modulating nitric oxide synthase and influencing pain and inflammation. Few human studies have specifically focused on athletic performance, endurance, or muscle growth. A handful of small-scale human studies or anecdotal reports suggest possible benefits in terms of perceived energy and recovery, but these findings are not robust or widely replicated.
In summary, while there is a plausible mechanistic basis and preliminary data from laboratory studies, the scientific evidence supporting agmatine for athletic and exercise enhancement is weak and insufficient for strong recommendations. More rigorous, well-controlled human trials are necessary to establish its efficacy and safety for this application.
Other ingredients used for Athletic and Exercise Aids
1,3,7-Trimethylpurine-2,6-dione7-Keto-DHEA
Acetyl L-carnitine
Acetyl-L-Tyrosine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Agmatine
Algae
Algal protein
Alpha D-ribofuranose
Alpha glyceryl
Alpha hydroxyisocaproic acid
alpha-ketoglutarate (AKG)
Alpha-ketoisocaproic acid
amino acids
antler
arachidonic acid
arginine alpha ketoglutarate
Arginine aspartate
arginine creatine
Arginine malate
Arginine nitrate
Arginine silicate
ashwagandha
astaxanthin
ba ji tian
bacillus subtilis
BCAA
bee pollen
Beef Protein
beet
beta-alanine
bicarbonate
black ginger
black tea
bovine
bovine protein
branched-chain amino acids
brown rice protein
Bulbine natalensis
caffeine
Camellia sinensis
capsaicinoids
capsiate
capsicum
capsinoids
cardarine
casein
cistanche
citrate malate
cocoa
coconut
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine
creatine monohydrate
curcumin
D-Aspartic Acid
D-Ribose
deer velvet
dihydrocapsiate
ecdysteroids
ecdysterone
electrolytes blend (proprietary)
eleuthero
elk antler
Ephedra
ephedrine
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Eurycoma Longifolia
eurycomanone
Fadogia agrestis
ginseng
Ginsenosides
glucose
Glutamine
Glycerol
Glycocyamine
GMS-ribose
green tea
guanidinoacetic acid
guarana
Guaranine
guayusa
Higenamine
HMB hydroxymethylbutyrate
horny goat weed
hydroxymethylbutyrate
Isoleucine
isomaltulose
jiaogulan
ketone salts
kola nut
L-alanine
L-alanyl-L-glutamine
L-arginine
l-carnitine
L-citrulline
L-glutamine
L-glycine
l-isoleucine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
lactalbumin
Laxogenin
maca
macaenes
macamides
magnesium
maral root
Mate
Methylliberine
Methylxanthine
Milk Protein
Mineral ascorbate
Muira puama
Mushroom
Nitrous Malate (TM) Diarginine Malate
omega-3 fatty acids
Ornithine
ornithine alpha-ketoglutarate
Palatinose
paraxanthine
Peppermint
Peptides
Phosphatidic Acid
Phosphocreatine
Phytoecdysteroid
Piper nigrum
protein
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline quinone
pyruvate
Quinoa Protein
Rhaponticum
Rhodiola
ribose
robusta coffee
Safed musli
salt
sea salt
Sida cordifolia
spirulina
suma
Synephrine
Teacrine
Theacrine
Theobromine
Tongkat ali
tribulus
Tribulus Terrestris
Trichilia catigua
Trichopus zeylanicus
Turkesterone
Valine alpha-hydroxyisocaproate
vitamin C
Watermelon
Whey protein
Xanthine
Yerba mate
Yohimbine