Amino acid chelates are minerals (such as iron, magnesium, zinc) bound to amino acids, which are thought to enhance the absorption and bioavailability of these minerals in the human body. Their use in athletic and exercise aids is primarily justified by scientific evidence, although the strength of evidence varies depending on the specific mineral and context. Studies have shown that athletes engaged in intense physical activity may have higher requirements for certain minerals due to losses through sweat and increased metabolic demand. Amino acid chelates may help optimize mineral status, support muscle function, reduce fatigue, and promote recovery.

For example, magnesium and zinc chelates have been studied for their potential roles in muscle contraction, energy metabolism, and immune function, all of which are relevant to athletic performance. Some clinical trials and reviews suggest that chelated forms can improve mineral absorption compared to inorganic salts, making them potentially more effective for replenishing deficiencies or supporting optimal physiological function in athletes.

However, while the bioavailability advantages of amino acid chelates are relatively well-established, direct evidence linking their supplementation to significant enhancements in exercise performance or recovery is less robust and sometimes inconsistent. The benefits appear most pronounced in individuals with existing mineral deficiencies. As such, the overall evidence for their use as athletic and exercise aids is moderate (rated 3/5), with further research needed to clarify their specific effects on performance outcomes.