Evidence supporting the use of: Cardarine
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Cardarine (GW501516) is a peroxisome proliferator-activated receptor delta (PPARδ) agonist that has been studied for its effects on metabolism and endurance. Preclinical studies in rodents have shown that Cardarine can increase fatty acid oxidation, enhance energy expenditure, and improve physical performance, leading to its informal use as an "exercise mimetic." Specifically, animal data suggest Cardarine increases running endurance and alters muscle gene expression to favor oxidative metabolism (Narkar et al., 2008). However, clinical research in humans is extremely limited. Small-scale human trials have shown some effects on lipid profiles, but robust data on athletic performance or safety in humans is lacking. Cardarine was never approved for medical use due to findings of cancer development in animal studies during long-term exposure. As a result, it is banned by the World Anti-Doping Agency (WADA) and is considered a prohibited substance in competitive sports. While its use as an athletic or exercise aid is based on mechanistic rationale and animal data, there is insufficient clinical evidence to support safety or efficacy in humans; thus, while there is some scientific validation in preclinical models, the overall evidence is weak and does not justify use.
Other ingredients used for Athletic and Exercise Aids
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
bacillus subtilis
beet
beta-alanine
black tea
bovine
branched-chain amino acids
caffeine
capsaicinoids
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
curcumin
eleuthero
ginseng
green tea
guarana
guayusa
l-isoleucine
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-taurine
l-tyrosine
l-valine
maca
magnesium
maltodextrin
muira puama
Acetyl-L-Tyrosine
omega-3 fatty acids
ornithine alpha-ketoglutarate
peppermint oil
protein
pyridoxal-5-phosphate (P-5-P)
rhodiola
black ginger
spirulina
tongkat ali
tribulus
vitamin C
watermelon
whey protein
suma
jiaogulan
capsicum
bee pollen
cistanche
electrolytes blend (proprietary)
yerba mate
algae
cocoa
brown rice protein
sea salt
1,3,7-Trimethylpurine-2,6-dione
2, 17a-dimethyl-17b-hydroxy-5a-androst-2-ene
Arginine Alpha Ketoglutarate
Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
Alpha glyceryl
Alpha-ketoisocaproic acid
Agmatine
adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine silicate
Bicarbonate
Beef Protein
Bovine Protein
Bulbine natalensis
Ba Ji Tian
BCAA
Camellia sinensis
Coconut
Casein
Cardarine
Capsinoids
Citrate malate
Capsiate
Creatine
D-Aspartic Acid
Dihydrocapsiate
Deer Velvet
D-Ribose
Ephedra
Elk antler
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
glucose
Isoleucine
Ketone Salts
Milk Protein
Quinoa Protein
salt
yohimbine
Other health conditions supported by Cardarine
Athletic and Exercise AidsBody Building
Cholesterol (high)
Fat Metabolism (poor)
Metabolic Syndrome
Triglycerides (high)
Weight Loss