Evidence supporting the use of: Citrulline nitrate
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Citrulline nitrate is a compound combining the amino acid citrulline with nitrate, both of which have been studied for their potential to enhance athletic performance. Scientific interest in citrulline stems from its role as a precursor to arginine and subsequently nitric oxide (NO), which may improve blood flow, oxygen delivery, and exercise performance. Nitrate, found naturally in foods like beetroot, is also known to increase NO production. Research on l-citrulline and nitrate supplementation individually has shown modest benefits for exercise performance, such as improved muscle endurance and reduced fatigue, particularly in high-intensity exercise.
However, direct studies on citrulline nitrate are limited. Early investigations suggest that citrulline nitrate may combine the benefits of both components, potentially enhancing vasodilation and exercise performance more effectively than either alone. A few small, acute studies in healthy subjects have reported improved blood flow and some improvements in exercise capacity, but the findings are not robust or consistent. Most of the available evidence comes from studies on citrulline malate or dietary nitrate, not the nitrate salt of citrulline specifically.
In summary, while the theoretical basis and some preliminary research provide a scientific rationale for the use of citrulline nitrate as an exercise aid, direct evidence is limited, and the quality of supporting studies is moderate to low. More high-quality, long-term clinical trials are needed to firmly establish its efficacy and safety for athletic and exercise performance.
More about Citrulline nitrate
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Other ingredients used for Athletic and Exercise Aids
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
bacillus subtilis
beet
beta-alanine
black tea
bovine
branched-chain amino acids
caffeine
capsaicinoids
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
curcumin
eleuthero
ginseng
green tea
guarana
guayusa
l-isoleucine
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-taurine
l-tyrosine
l-valine
maca
magnesium
maltodextrin
muira puama
Acetyl-L-Tyrosine
omega-3 fatty acids
ornithine alpha-ketoglutarate
peppermint oil
protein
pyridoxal-5-phosphate (P-5-P)
rhodiola
black ginger
spirulina
tongkat ali
tribulus
vitamin C
watermelon
whey protein
suma
jiaogulan
capsicum
bee pollen
cistanche
electrolytes blend (proprietary)
yerba mate
algae
cocoa
brown rice protein
sea salt
1,3,7-Trimethylpurine-2,6-dione
2, 17a-dimethyl-17b-hydroxy-5a-androst-2-ene
Arginine Alpha Ketoglutarate
Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
Alpha glyceryl
Alpha-ketoisocaproic acid
Agmatine
adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine silicate
Bicarbonate
Beef Protein
Bovine Protein
Bulbine natalensis
Ba Ji Tian
BCAA
Camellia sinensis
Coconut
Casein
Cardarine
Capsinoids
Citrate malate
Capsiate
Creatine
D-Aspartic Acid
Dihydrocapsiate
Deer Velvet
D-Ribose
Ephedra
Eurycomanone
Elk antler
Eurycoma Longifolia
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
Fadogia agrestis
Glutamine
glucose
Glycerol
Isoleucine
Ketone Salts
Milk Protein
Quinoa Protein
salt
yohimbine
Other health conditions supported by Citrulline nitrate
Athletic and Exercise AidsCirculation (poor)
Erectile Dysfunction
Fatigue