Evidence supporting the use of: Creatine leucinate
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Creatine leucinate is a form of creatine in which creatine is bound to the amino acid leucine. There is a strong scientific basis for the use of creatine monohydrate as an athletic and exercise aid, primarily for improving strength, power, and lean body mass. However, specific research on creatine leucinate is limited compared to the extensive studies on creatine monohydrate. The rationale for combining creatine with leucine is to potentially enhance muscle protein synthesis due to leucine's known role in stimulating the mTOR pathway, which regulates muscle growth. Some preliminary studies and theoretical mechanisms suggest that creatine leucinate may offer combined benefits for muscle energy (from creatine) and anabolic signaling (from leucine), but robust clinical trials validating its efficacy over standard creatine or leucine supplementation are lacking. Therefore, while the use of creatine leucinate as an exercise aid is scientifically plausible and builds upon validated principles, the direct supporting evidence for this specific compound is moderate at best. Most recommendations are extrapolated from the well-established effects of its individual components, not from direct studies on creatine leucinate itself.
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