Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Guayusa (Ilex guayusa) is a caffeinated leaf native to the Amazon rainforest, traditionally used by indigenous peoples in Ecuador as a stimulating beverage, much like yerba mate or tea. Its use as an athletic and exercise aid is primarily justified by its caffeine content, which is well known to enhance alertness, reduce perceived exertion, and improve endurance performance in both scientific and athletic communities. Several studies on caffeine (the primary active compound in guayusa) have demonstrated its ergogenic effects, including increased stamina, improved reaction time, and enhanced cognitive function during exercise. While there are very few clinical studies specifically evaluating guayusa in athletes, its caffeine levels—comparable to or slightly less than coffee or yerba mate—make it a logical substitute for other caffeine sources used in sports nutrition.

A small number of preliminary studies suggest that guayusa may also contain antioxidants and polyphenols, which could theoretically help with oxidative stress induced by exercise, but these effects have not been robustly studied in human trials. Thus, while there is indirect scientific support for guayusa as an exercise aid due to its caffeine and antioxidant content, direct evidence from rigorous clinical trials is limited. Most claims about its efficacy for athletic performance are therefore extrapolated from broader research on caffeine, rather than guayusa-specific studies. In summary, guayusa is used as an exercise aid primarily because of its caffeine content, with moderate but not conclusive scientific support.

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