Evidence supporting the use of: Ketone salts
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Ketone salts are used as an athletic and exercise aid based on emerging scientific interest, rather than a longstanding tradition. The premise is that exogenous ketones (such as ketone salts) can rapidly elevate blood ketone levels, mimicking the metabolic state of ketosis achieved through prolonged fasting or a ketogenic diet. This could, in theory, provide an alternative energy substrate for muscles and the brain during exercise, possibly sparing muscle glycogen and delaying fatigue. However, the scientific validation for their effectiveness is limited and mixed. Some small studies have shown that exogenous ketones can elevate blood beta-hydroxybutyrate and alter substrate utilization during exercise. For example, early research suggested that ketone supplementation might improve endurance performance or recovery by providing an efficient fuel source. Nevertheless, subsequent trials have generally found little to no benefit in athletic performance, and in some cases, ketone salts have been associated with gastrointestinal distress and reduced exercise capacity, likely due to the high mineral load. A 2021 systematic review concluded that exogenous ketone supplementation does not consistently improve performance in endurance or high-intensity exercise. Most studies are limited by small sample sizes, short duration, and varying protocols. As such, while the use of ketone salts as an exercise aid is based on plausible mechanisms and preliminary research, robust scientific evidence supporting their effectiveness is lacking.
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Other ingredients used for Athletic and Exercise Aids
1,3,7-Trimethylpurine-2,6-dione7-Keto-DHEA
Acetyl L-carnitine
Acetyl-L-Tyrosine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Agmatine
Algae
Algal protein
Alpha D-ribofuranose
Alpha glyceryl
Alpha hydroxyisocaproic acid
alpha-ketoglutarate (AKG)
Alpha-ketoisocaproic acid
amino acids
antler
arachidonic acid
arginine alpha ketoglutarate
Arginine aspartate
arginine creatine
Arginine malate
Arginine nitrate
Arginine silicate
ashwagandha
astaxanthin
ba ji tian
bacillus subtilis
BCAA
bee pollen
Beef Protein
beet
beta-alanine
bicarbonate
black ginger
black tea
bovine
bovine protein
branched-chain amino acids
brown rice protein
Bulbine natalensis
caffeine
Camellia sinensis
capsaicinoids
capsiate
capsicum
capsinoids
cardarine
casein
cistanche
citrate malate
cocoa
coconut
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine
creatine monohydrate
curcumin
D-Aspartic Acid
D-Ribose
deer velvet
dihydrocapsiate
ecdysteroids
ecdysterone
electrolytes blend (proprietary)
eleuthero
elk antler
Ephedra
ephedrine
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Eurycoma Longifolia
eurycomanone
Fadogia agrestis
ginseng
Ginsenosides
glucose
Glutamine
Glycerol
Glycocyamine
GMS-ribose
green tea
guanidinoacetic acid
guarana
Guaranine
guayusa
Higenamine
HMB hydroxymethylbutyrate
horny goat weed
hydroxymethylbutyrate
Isoleucine
isomaltulose
jiaogulan
ketone salts
kola nut
L-alanine
L-alanyl-L-glutamine
L-arginine
l-carnitine
L-citrulline
L-glutamine
L-glycine
l-isoleucine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
lactalbumin
Laxogenin
maca
macaenes
macamides
magnesium
maral root
Mate
Methylliberine
Methylxanthine
Milk Protein
Mineral ascorbate
Muira puama
Mushroom
Nitrous Malate (TM) Diarginine Malate
omega-3 fatty acids
Ornithine
ornithine alpha-ketoglutarate
Palatinose
paraxanthine
Peppermint
Peptides
Phosphatidic Acid
Phosphocreatine
Phytoecdysteroid
Piper nigrum
protein
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline quinone
pyruvate
Quinoa Protein
Rhaponticum
Rhodiola
ribose
robusta coffee
Safed musli
salt
sea salt
Sida cordifolia
spirulina
suma
Synephrine
Teacrine
Theacrine
Theobromine
Tongkat ali
tribulus
Tribulus Terrestris
Trichilia catigua
Trichopus zeylanicus
Turkesterone
Valine alpha-hydroxyisocaproate
vitamin C
Watermelon
Whey protein
Xanthine
Yerba mate
Yohimbine
Other health conditions supported by ketone salts
Alzheimer's DiseaseAthletic and Exercise Aids
Dementia
Energy (lack of)
Epilepsy
Exercise
Fatigue
Migraine