Evidence supporting the use of: L-norvaline
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 1
L-norvaline is a non-proteinogenic amino acid that has been included in some dietary supplements marketed for athletic and exercise performance, primarily due to claims that it enhances nitric oxide (NO) production. The rationale is that L-norvaline inhibits arginase, an enzyme that breaks down arginine, theoretically leading to increased arginine availability for nitric oxide synthase and thus more NO, which may enhance blood flow and exercise performance. However, scientific evidence supporting these claims is limited and of low quality. Most studies on L-norvaline’s effects are preclinical, involving in vitro experiments or animal models. Human research is sparse and does not robustly demonstrate improvements in athletic performance, endurance, or muscle strength. Additionally, safety concerns have been raised; a 2019 study reported potential neurotoxicity of L-norvaline at high concentrations in vitro, though the relevance to standard supplement dosages is unclear. Major sports medicine and nutrition organizations do not endorse L-norvaline supplementation, and it is not considered an evidence-based ergogenic aid. In summary, while there is a theoretical basis and some mechanistic support for its use from laboratory research, there is insufficient clinical evidence to justify its use as an exercise or athletic aid.
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Other ingredients used for Athletic and Exercise Aids
7-Keto-DHEAacetyl l-carnitine
adenosine 5-triphosphate disodium (ATP)
alpha d-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
bacillus subtilis
beet
beta-alanine
black tea
bovine
branched-chain amino acids
caffeine
capsaicinoids
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
curcumin
eleuthero
ginseng
green tea
guarana
guayusa
l-isoleucine
l-alanine
l-alanyl-l-glutamine
l-arginine
l-carnitine
l-citrulline
l-glutamine
l-glycine
l-leucine
l-ornithine
l-taurine
l-tyrosine
l-valine
maca
magnesium
maltodextrin
muira puama
Acetyl-L-Tyrosine
omega-3 fatty acids
ornithine alpha-ketoglutarate
peppermint oil
protein
pyridoxal-5-phosphate (P-5-P)
rhodiola
black ginger
spirulina
tongkat ali
tribulus
vitamin C
watermelon
whey protein
suma
jiaogulan
capsicum
bee pollen
cistanche
electrolytes blend (proprietary)
yerba mate
algae
cocoa
brown rice protein
sea salt
1,3,7-Trimethylpurine-2,6-dione
2, 17a-dimethyl-17b-hydroxy-5a-androst-2-ene
Arginine Alpha Ketoglutarate
Antler
Arginine Creatine
Arginine nitrate
Arachidonic Acid
Arginine malate
Arginine aspartate
Alpha glyceryl
Alpha-ketoisocaproic acid
Agmatine
adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine silicate
Bicarbonate
Beef Protein
Bovine Protein
Bulbine natalensis
Ba Ji Tian
BCAA
Camellia sinensis
Coconut
Casein
Cardarine
Capsinoids
Citrate malate
Capsiate
Creatine
D-Aspartic Acid
Dihydrocapsiate
Deer Velvet
D-Ribose
Ephedra
Elk antler
Ecdysteroids
Elthyl-Alpha-Guanido-Methyl-Ethanoate
Ecdysterone
Ephedrine
glucose
Isoleucine
Ketone Salts
Milk Protein
Quinoa Protein
salt
yohimbine