Evidence supporting the use of: Methylliberine
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Methylliberine, commonly known as "Dynamine," is a purine alkaloid structurally similar to caffeine and theacrine. It is increasingly found in pre-workout and energy supplements marketed to athletes and fitness enthusiasts. The rationale for its inclusion is based on its purported ability to increase energy, enhance alertness, and possibly improve mood, much like caffeine but with a potentially different side-effect profile. Scientific evidence supporting methylliberine’s use for athletic and exercise performance is still limited and emerging. A small number of studies have investigated its safety and pharmacokinetics, with some suggesting that it can increase feelings of energy and alertness without significantly affecting blood pressure or heart rate. One randomized, double-blind crossover study found that methylliberine, alone or combined with theacrine and caffeine, increased subjective energy and mood but did not robustly enhance objective physical performance measures. There is currently a lack of large, well-controlled human trials directly demonstrating improvements in exercise capacity, endurance, or strength. Most available evidence is preliminary, and more research is needed to determine its efficacy and safety for athletic performance. Therefore, while there is a plausible scientific basis and early data suggesting potential benefits, the overall evidence is modest (rated 2/5) and not yet conclusive.
More about Methylliberine
More about Athletic and Exercise Aids
Other ingredients used for Athletic and Exercise Aids
1,3,7-Trimethylpurine-2,6-dione7-Keto-DHEA
Acetyl L-carnitine
Acetyl-L-Tyrosine
adenosine 5-triphosphate disodium (ATP)
Adenosine triphosphate (ATP)
Agmatine
Algae
Algal protein
Alpha D-ribofuranose
Alpha glyceryl
Alpha hydroxyisocaproic acid
alpha-ketoglutarate (AKG)
Alpha-ketoisocaproic acid
amino acids
antler
arachidonic acid
arginine alpha ketoglutarate
Arginine aspartate
arginine creatine
Arginine malate
Arginine nitrate
Arginine silicate
ashwagandha
astaxanthin
ba ji tian
bacillus subtilis
BCAA
bee pollen
Beef Protein
beet
beta-alanine
bicarbonate
black ginger
black tea
bovine
bovine protein
branched-chain amino acids
brown rice protein
Bulbine natalensis
caffeine
Camellia sinensis
capsaicinoids
capsiate
capsicum
capsinoids
cardarine
casein
cistanche
citrate malate
cocoa
coconut
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine
creatine monohydrate
curcumin
D-Aspartic Acid
D-Ribose
deer velvet
dihydrocapsiate
ecdysteroids
ecdysterone
electrolytes blend (proprietary)
eleuthero
elk antler
Ephedra
ephedrine
Ethyl-Alpha-Guanido-Methyl-Ethanoate
Eurycoma Longifolia
eurycomanone
Fadogia agrestis
ginseng
Ginsenosides
glucose
Glutamine
Glycerol
Glycocyamine
GMS-ribose
green tea
guanidinoacetic acid
guarana
Guaranine
guayusa
Higenamine
HMB hydroxymethylbutyrate
horny goat weed
hydroxymethylbutyrate
Isoleucine
isomaltulose
jiaogulan
ketone salts
kola nut
L-alanine
L-alanyl-L-glutamine
L-arginine
l-carnitine
L-citrulline
L-glutamine
L-glycine
l-isoleucine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
lactalbumin
Laxogenin
maca
macaenes
macamides
magnesium
maral root
Mate
Methylliberine
Methylxanthine
Milk Protein
Mineral ascorbate
Muira puama
Mushroom
Nitrous Malate (TM) Diarginine Malate
omega-3 fatty acids
Ornithine
ornithine alpha-ketoglutarate
Palatinose
paraxanthine
Peppermint
Peptides
Phosphatidic Acid
Phosphocreatine
Phytoecdysteroid
Piper nigrum
protein
pyridoxal-5-phosphate (P-5-P)
pyrroloquinoline quinone
pyruvate
Quinoa Protein
Rhaponticum
Rhodiola
ribose
robusta coffee
Safed musli
salt
sea salt
Sida cordifolia
spirulina
suma
Synephrine
Teacrine
Theacrine
Theobromine
Tongkat ali
tribulus
Tribulus Terrestris
Trichilia catigua
Trichopus zeylanicus
Turkesterone
Valine alpha-hydroxyisocaproate
vitamin C
Watermelon
Whey protein
Xanthine
Yerba mate
Yohimbine
Other health conditions supported by Methylliberine
Athletic and Exercise AidsConcentration (poor)
Energy (lack of)
Fatigue
Thinking (cloudy)