Evidence supporting the use of: Pyruvate
For the health condition: Athletic and Exercise Aids
Synopsis
Source of validity: Scientific
Rating (out of 5): 1
Pyruvate has been promoted as an athletic and exercise aid based on its role as an end-product of glycolysis and its involvement in cellular energy metabolism. The theoretical rationale is that supplemental pyruvate could enhance energy production, improve exercise performance, and support weight loss by increasing fat oxidation. However, scientific validation for these claims is limited.
Several small clinical trials have investigated the effects of pyruvate supplementation on exercise performance and body composition. Most studies used relatively high doses (15–30 grams per day), and results have been inconsistent. A few early studies suggested that pyruvate might have modest benefits for endurance or weight loss, but methodological flaws, small sample sizes, and short durations limit the reliability of these findings. Larger, more rigorous trials have failed to show significant improvements in exercise performance, endurance, or muscle strength with pyruvate supplementation compared to placebo.
Furthermore, the high doses of pyruvate used in studies often resulted in gastrointestinal side effects, and its bioavailability when taken orally is low. The International Society of Sports Nutrition and other expert groups currently conclude that there is insufficient evidence to support the use of pyruvate as an effective athletic or exercise aid. Thus, while the use is based on plausible biochemical theory, scientific evidence supporting its efficacy is minimal.
Other ingredients used for Athletic and Exercise Aids
7-Keto-DHEAAcetyl L-carnitine
adenosine 5-triphosphate disodium (ATP)
Alpha D-ribofuranose
alpha-ketoglutarate (AKG)
amino acids
ashwagandha
astaxanthin
bacillus subtilis
beet
beta-alanine
black tea
bovine
branched-chain amino acids
caffeine
capsaicinoids
coenzyme Q10 (CoQ10)
collagen
colostrum
conjugated linoleic acid (CLA)
cordyceps
creatine monohydrate
curcumin
eleuthero
ginseng
green tea
guarana
guayusa
l-isoleucine
L-alanine
L-alanyl-L-glutamine
L-arginine
l-carnitine
L-citrulline
L-glutamine
L-glycine
L-leucine
L-ornithine
L-taurine
l-tyrosine
L-valine
maca
magnesium
maltodextrin
Muira puama
Acetyl-L-Tyrosine
omega-3 fatty acids
ornithine alpha-ketoglutarate
Peppermint
protein
pyridoxal-5-phosphate (P-5-P)
Rhodiola
black ginger
spirulina
Tongkat ali
tribulus
vitamin C
Watermelon
Whey protein
suma
jiaogulan
capsicum
bee pollen
cistanche
electrolytes blend (proprietary)
Yerba mate
Algae
cocoa
brown rice protein
sea salt
1,3,7-Trimethylpurine-2,6-dione
arginine alpha ketoglutarate
antler
arginine creatine
Arginine nitrate
arachidonic acid
Arginine malate
Arginine aspartate
Alpha glyceryl
Alpha-ketoisocaproic acid
Agmatine
Adenosine triphosphate (ATP)
Algal protein
Alpha hydroxyisocaproic acid
Arginine silicate
bicarbonate
Beef Protein
bovine protein
Bulbine natalensis
ba ji tian
BCAA
Camellia sinensis
coconut
casein
cardarine
capsinoids
citrate malate
capsiate
creatine
D-Aspartic Acid
dihydrocapsiate
deer velvet
D-Ribose
Ephedra
eurycomanone
elk antler
Eurycoma Longifolia
ecdysteroids
Ethyl-Alpha-Guanido-Methyl-Ethanoate
ecdysterone
ephedrine
Fadogia agrestis
guanidinoacetic acid
Ginsenosides
Glutamine
Growth factors
GMS-ribose
glucose
Glycocyamine
Guaranine
Glycerol
Higenamine
hydroxymethylbutyrate
HMB hydroxymethylbutyrate
horny goat weed
isomaltulose
Isoleucine
kola nut
ketone salts
lactalbumin
Laxogenin
macamides
maral root
Mineral ascorbate
Milk Protein
Methylxanthine
Methylliberine
Mate
Mushroom
macaenes
Nitrous Malate (TM) Diarginine Malate
Ornithine
Phosphocreatine
pyrroloquinoline quinone
paraxanthine
Phytoecdysteroid
pyruvate
Phosphatidic Acid
Piper nigrum
Palatinose
Peptides
Quinoa Protein
Rhaponticum
ribose
robusta coffee
Synephrine
Safed musli
salt
Sida cordifolia
Theobromine
Tripeptide
Trichilia catigua
Turkesterone
Trichopus zeylanicus
Theacrine
Teacrine
Tribulus Terrestris
Valine alpha-hydroxyisocaproate
Xanthine
Yohimbine