Evidence supporting the use of: Alkaloid
For the health condition: Attention Deficit Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Alkaloids, specifically those in the stimulant class such as amphetamine and methylphenidate, are scientifically validated treatments for Attention Deficit Disorder (ADD), more commonly referred to as Attention Deficit Hyperactivity Disorder (ADHD). These compounds are central nervous system stimulants that increase the synaptic concentrations of neurotransmitters like dopamine and norepinephrine, which are thought to be deficient in individuals with ADHD. Numerous double-blind, placebo-controlled clinical trials have demonstrated that these alkaloids significantly reduce core ADHD symptoms, including inattention, hyperactivity, and impulsivity. Systematic reviews and meta-analyses consistently rate stimulant medications as the most effective pharmacological treatment for ADHD in both children and adults. The efficacy and safety profile of these alkaloids has led to their approval by major regulatory agencies such as the FDA and EMA. While not all alkaloids are used for ADHD, those in the stimulant category have robust scientific support for their use in this condition, making the evidence base among the strongest in psychopharmacology.

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