Evidence supporting the use of: Citicholine
For the health condition: Attention Deficit Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citicoline (CDP-choline) has been investigated for its potential to support cognitive function, including in Attention Deficit Disorder (ADD/ADHD). The scientific justification for its use rests on its role as a precursor to the neurotransmitter acetylcholine and as a phospholipid donor for cell membrane repair, both of which are important for brain health and cognitive processes.

Several small clinical trials and open-label studies have evaluated citicoline’s effects on attention and impulsivity, primarily in children and adolescents with ADHD. Some studies indicate modest improvements in attention, impulsivity, and executive function. For example, a double-blind, placebo-controlled study published in 2014 (Ramos-Quiroga et al.) found that citicoline supplementation led to statistically significant but modest improvements in attention measures in children diagnosed with ADHD. However, the effect size was small and less robust compared to standard stimulant medications. Other studies have shown mixed or inconclusive results, with some not finding significant benefits over placebo.

Overall, while there is some scientific exploration into citicoline’s use for attention deficits, the evidence base is limited in quality and size. Citicoline is not widely endorsed in clinical guidelines for ADD/ADHD, and more rigorous, large-scale, and long-term studies are needed to determine its true efficacy. Its use is considered experimental or adjunctive rather than a primary or standard therapy for attention disorders.

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