Evidence supporting the use of: Citicoline
For the health condition: Attention Deficit Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citicoline (also known as CDP-choline) is a naturally occurring compound involved in brain metabolism. Its primary scientific rationale for use in Attention Deficit Disorder (ADD/ADHD) stems from its role in enhancing neurotransmitter synthesis (especially acetylcholine and dopamine), which are critical for attention and executive function. Several small studies and clinical trials have explored citicoline as a potential cognitive enhancer, with some preliminary evidence suggesting improvements in attention, mental energy, and focus, particularly in populations with cognitive impairment. For ADHD specifically, research is limited but promising: a few pilot studies and open-label trials in children and adolescents with ADHD have demonstrated modest improvements in attention and impulse control when citicoline is used as a supplement.

Despite these findings, the overall quality of evidence is low: sample sizes are small, studies often lack rigorous controls, and results are not always consistent. There is not yet a large body of high-quality, placebo-controlled trials supporting citicoline as a primary or adjunctive treatment for ADHD. It is not considered a first-line therapy, and major clinical guidelines do not currently endorse its use for this condition. In summary, while the rationale for using citicoline in ADD/ADHD is supported by some scientific studies and plausible neurochemical mechanisms, the evidence is preliminary and insufficient for strong recommendations. Further research with larger, well-designed trials is needed to establish its efficacy and safety profile in this population.

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