Evidence supporting the use of: Nicotine
For the health condition: Attention Deficit Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Nicotine has been investigated as a potential treatment for Attention Deficit Disorder (ADD) and Attention Deficit Hyperactivity Disorder (ADHD) due to its stimulant properties and its action on nicotinic acetylcholine receptors in the brain. Some scientific studies have found that nicotine can transiently improve attention, working memory, and other cognitive processes in both healthy individuals and those with ADHD. This is likely because nicotine increases the release of neurotransmitters such as dopamine and norepinephrine, which are also modulated by standard ADHD medications like methylphenidate and amphetamines.

However, the evidence for using nicotine as a therapeutic agent in ADHD is limited and mixed. Most research consists of small-scale studies or short-term trials, often using nicotine patches or gum rather than tobacco products. Some studies report modest improvements in attention or impulse control, while others find minimal or no benefit. Importantly, the risks associated with nicotine use—including addiction, cardiovascular effects, and other adverse health outcomes—greatly outweigh any potential benefit, especially in children and adolescents.

Nicotine is not approved by regulatory agencies for the treatment of ADD or ADHD, and its use is not recommended in clinical guidelines. Its investigation in this context is primarily of scientific interest rather than clinical practice, and current evidence does not support its use as a safe or effective treatment.

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