Evidence supporting the use of: Phosphatidylserine complex
For the health condition: Attention Deficit Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Phosphatidylserine is a phospholipid found in high concentrations in the brain and is involved in cell signaling and the maintenance of cellular function. Its use in supporting Attention Deficit Disorder (ADD, often now referred to as ADHD) has some basis in scientific investigation, though the evidence is limited and not conclusive. A few small-scale, randomized, controlled studies have examined phosphatidylserine supplementation in children with ADHD symptoms. For example, a 2012 double-blind, placebo-controlled study published in European Psychiatry found that a combination supplement containing phosphatidylserine and omega-3 fatty acids showed some improvement in attention and impulsivity in a small group of children. Another 2014 study in Food & Nutrition Research investigated soy-derived phosphatidylserine and reported modest benefit in ADHD symptoms.

However, these studies are limited by small sample sizes, short duration, and sometimes by using phosphatidylserine in combination with other nutrients, making it difficult to attribute observed effects solely to phosphatidylserine. Systematic reviews and meta-analyses have concluded that while there is some preliminary evidence for benefit, the quality and quantity of data are insufficient to make strong recommendations. Overall, the scientific foundation for using phosphatidylserine in ADHD is weak to moderate at best, and phosphatidylserine should not be considered a first-line or primary treatment for ADD/ADHD.

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