Evidence supporting the use of: Omega-3
For the health condition: Autism

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Omega-3 fatty acids, particularly EPA and DHA found in fish oil, have been investigated as a potential adjunctive treatment for autism spectrum disorder (ASD). The rationale is based on omega-3s’ roles in brain development, neurotransmission, and anti-inflammatory processes. Some observational studies have reported lower levels of omega-3 in children with ASD compared to neurotypical peers. However, the clinical trial evidence is limited and mixed. Several small randomized controlled trials (RCTs) have assessed the effects of omega-3 supplementation on core ASD symptoms (such as social interaction, communication, and repetitive behaviors) as well as associated symptoms (hyperactivity, irritability). Most of these studies report minimal or no significant benefit, though a few suggest modest improvements in hyperactivity or stereotypy. Systematic reviews and meta-analyses, such as those published in JAMA Pediatrics (2017) and Cochrane Database (2011, updated 2020), conclude that there is insufficient evidence to recommend omega-3 supplements for ASD treatment. The overall quality of the evidence is low to moderate due to small sample sizes and heterogeneity in outcome measures. In summary, while there is a scientific rationale and some preliminary evidence, robust scientific validation is lacking and omega-3 should not be considered a primary or proven therapy for autism.

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Products containing Omega-3

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