Evidence supporting the use of: 11-keto-beta-boswellic acid
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

11-keto-beta-boswellic acid (KBA) is a bioactive component derived from the resin of Boswellia serrata, commonly known as frankincense. This compound has garnered research interest due to its anti-inflammatory properties, which are primarily attributed to its ability to inhibit 5-lipoxygenase (5-LOX), a key enzyme in leukotriene synthesis associated with inflammation. Several preclinical studies have demonstrated that KBA and related boswellic acids can suppress inflammatory pathways, reduce cytokine production, and modulate immune responses in models of autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. However, the majority of evidence comes from in vitro and animal studies; there are only limited human clinical trials, and these typically involve boswellia extracts rather than isolated KBA. The available clinical evidence suggests potential benefits in managing symptoms of certain autoimmune conditions, but the quality and quantity of data are insufficient for definitive recommendations. Thus, while there is a scientific rationale and some supportive data for using KBA in autoimmune disorders, the overall level of evidence remains low, and more rigorous clinical trials are needed to confirm its efficacy and safety.

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