Evidence supporting the use of: 3-Ketosteroid
For the health condition: Autoimmune Disorders

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

3-Ketosteroids, such as prednisone and other corticosteroids, are scientifically validated medications widely used in the management of autoimmune disorders. The primary mechanism involves potent anti-inflammatory and immunosuppressive effects, which help to modulate the overactive immune response characteristic of autoimmune diseases. Clinical evidence from numerous randomized controlled trials and decades of clinical use supports their efficacy in conditions such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis exacerbations, autoimmune hepatitis, and inflammatory bowel disease, among others.

The immunosuppressive action of 3-ketosteroids is mediated by their ability to bind to glucocorticoid receptors, leading to altered gene transcription. This results in the downregulation of pro-inflammatory cytokines and inhibition of immune cell proliferation and activation. While effective in reducing disease activity and flares, long-term use is associated with significant side effects, including increased risk of infection, osteoporosis, hypertension, and metabolic disturbances. Consequently, these drugs are often used at the lowest effective dose for the shortest duration necessary, and newer therapies are being developed to minimize adverse effects.

In summary, the use of 3-ketosteroids in autoimmune disorders is strongly supported by scientific evidence, making them a cornerstone in the treatment of these conditions, particularly for acute management and disease flares.

More about 3-Ketosteroid
More about Autoimmune Disorders

Other health conditions supported by 3-Ketosteroid

Autoimmune Disorders
Inflammation

Products containing 3-Ketosteroid

We currently have no products on Vitabase that contain this ingredient.