Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha lipoic acid (ALA) is an antioxidant compound that has been investigated for its potential to modulate immune responses and reduce inflammation, which are central to autoimmune disorders. The scientific rationale for its use comes from several preclinical studies and a limited number of clinical trials. In vitro and animal studies suggest that ALA can suppress the activation of nuclear factor kappa B (NF-κB), a transcription factor involved in promoting inflammation, and can reduce the production of pro-inflammatory cytokines. These properties have led researchers to explore ALA as a supportive therapy in conditions such as multiple sclerosis (MS), rheumatoid arthritis (RA), and lupus. In humans, the best evidence is for multiple sclerosis, where small clinical trials have demonstrated that ALA supplementation (typically 1200 mg daily) may reduce markers of inflammation and slow disease progression. For example, a randomized controlled trial in patients with secondary progressive MS found some beneficial effects on inflammatory biomarkers. However, results are inconsistent, and larger, more rigorous studies are needed. Evidence for other autoimmune diseases is mostly limited to animal models or case reports. Overall, while there is a scientific basis and some preliminary clinical data for the use of alpha lipoic acid in autoimmune disorders, the evidence remains weak (rated 2/5). It may be considered as a complementary approach, but it is not a substitute for conventional medical treatment, and patients should consult their healthcare provider before use.

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Other ingredients used for Autoimmune Disorders

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Products containing alpha lipoic acid

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