Evidence supporting the use of: Bacillus subtilis
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacillus subtilis is a probiotic bacterium occasionally studied for its immunomodulatory effects, but its use in supporting or treating autoimmune disorders is based on limited and preliminary scientific evidence. Some animal studies and in vitro experiments suggest that Bacillus subtilis may influence immune responses by modulating cytokine production, enhancing gut barrier function, and promoting regulatory T cell activity. For example, certain strains of Bacillus subtilis have demonstrated the ability to reduce inflammation in models of colitis and other immune-mediated conditions in mice. These effects may, in theory, be beneficial in autoimmune diseases, which are characterized by dysregulated immune responses.

However, robust human clinical trials exploring the efficacy and safety of Bacillus subtilis specifically for autoimmune disorders are lacking. Most available studies involve animal models or focus on general gut health and immune modulation rather than direct treatment of specific autoimmune diseases such as rheumatoid arthritis, lupus, or multiple sclerosis. While some commercial probiotic supplements containing Bacillus subtilis are marketed for immune support, explicit claims for autoimmune disorder treatment are not substantiated by high-quality clinical evidence.

In summary, the scientific basis for using Bacillus subtilis in autoimmune disorders is preliminary and insufficient for strong recommendations. Evidence is rated as 2/5 due to the promising preclinical data but lack of robust human studies. Individuals with autoimmune disorders should consult healthcare professionals before considering probiotics as part of their treatment strategy.

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