Evidence supporting the use of: Epigallocatechin gallate
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG), the principal catechin in green tea, has garnered interest for its potential immunomodulatory effects. Preclinical studies indicate that EGCG can influence immune system pathways, notably by modulating T-cell activity, suppressing pro-inflammatory cytokines, and inhibiting NF-κB signaling. These actions suggest potential benefits in autoimmune conditions where immune dysregulation causes tissue damage.

Animal models provide the majority of evidence. For example, EGCG administration has shown to ameliorate symptoms in mouse models of multiple sclerosis (experimental autoimmune encephalomyelitis), rheumatoid arthritis, and lupus, often through reduction of inflammatory cell infiltration and cytokine production. Some in vitro studies using human immune cells show EGCG can decrease markers of inflammation relevant to autoimmune pathogenesis.

However, clinical evidence in humans is limited and mostly preliminary. A handful of small, early-phase clinical trials have explored EGCG in autoimmune diseases such as multiple sclerosis and Sjögren’s syndrome, with modest and inconsistent effects. No large, well-controlled human trials currently support EGCG as an established treatment for autoimmune disorders. Safety at higher supplemental doses, which may be required for therapeutic effects, is also not fully established.

In summary, while there is promising preclinical evidence supporting EGCG’s potential for modulating autoimmune processes, human data remain insufficient. Thus, scientific backing exists but is currently weak, justifying a moderate rating.

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