Evidence supporting the use of: Globulins
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Globulins, particularly immunoglobulins (antibodies), have scientific validation for their use in certain autoimmune disorders. The best-known preparation is Intravenous Immunoglobulin (IVIG), which is a blood product containing pooled IgG antibodies from many donors. IVIG is utilized in the management of various autoimmune diseases, such as immune thrombocytopenia (ITP), Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), myasthenia gravis, and Kawasaki disease, among others. The evidence for IVIG’s efficacy comes from randomized controlled trials, meta-analyses, and systematic reviews. IVIG is believed to act through multiple mechanisms, including modulation of the immune system, neutralization of autoantibodies, inhibition of complement activation, and suppression of inflammatory mediators. Clinical guidelines from organizations such as the American Academy of Neurology and the American Society of Hematology recommend IVIG in specific autoimmune conditions where it has demonstrated benefit. However, IVIG use is typically reserved for cases that are severe, refractory, or where other treatments have failed, due to the high cost and potential side effects (such as infusion reactions and, rarely, thromboembolic events). Importantly, not all globulins or immunoglobulin preparations are used for all autoimmune diseases, and their use should be based on specific indications and under specialist supervision.

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