Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Green lipped mussel (Perna canaliculus), native to New Zealand, is primarily used for its anti-inflammatory properties. Its use in autoimmune disorders, particularly rheumatoid arthritis (RA), is supported by a modest body of scientific literature. The mussel contains omega-3 polyunsaturated fatty acids, glycosaminoglycans, and other bioactive compounds believed to modulate inflammatory pathways. Several small clinical trials and animal studies have shown green lipped mussel extract can reduce joint pain, stiffness, and improve mobility in people with RA and osteoarthritis. For example, randomized controlled trials have reported statistically significant improvements in pain scores and reductions in inflammation markers, though the effects are generally mild to moderate and studies tend to be small and of variable quality.

There is limited direct evidence for its efficacy in other autoimmune diseases (such as lupus or multiple sclerosis), though its general anti-inflammatory action provides a theoretical basis for benefit. It is not a replacement for conventional therapies but may serve as an adjunct. Safety profiles are generally favorable, with rare reports of gastrointestinal upset or allergic reaction. Overall, scientific evidence exists but is not robust; more large, high-quality studies are needed to confirm benefit and clarify which autoimmune conditions might respond best to supplementation.

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