Evidence supporting the use of: Lactobacillus johnsonii
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus johnsonii is a probiotic bacterium that has been the subject of several preclinical studies investigating its potential role in modulating immune responses and supporting autoimmune health. Animal studies, particularly in mouse models, have shown that L. johnsonii can influence immune regulation, including increasing regulatory T cell populations and decreasing pro-inflammatory responses. For example, research has demonstrated that supplementation with L. johnsonii can reduce the severity of autoimmune diseases such as type 1 diabetes and multiple sclerosis in animal models by altering gut microbiota composition and enhancing gut barrier integrity.

However, evidence in humans remains very limited. There are only a few small-scale clinical trials examining L. johnsonii in autoimmune conditions, and results are preliminary. Most human studies focus on its general immunomodulatory properties or its use in gastrointestinal health, rather than direct effects on autoimmune disease outcomes. The theoretical basis for its use in autoimmune disorders stems from the "hygiene hypothesis" and the understanding that gut microbiota can influence systemic immune balance.

In summary, while there is promising preclinical evidence suggesting immunoregulatory effects of L. johnsonii, robust clinical trials in humans are lacking. Therefore, its use to support or treat autoimmune disorders is based on early scientific evidence, with a current evidence rating of 2/5.

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