Evidence supporting the use of: Lactococcus lactis
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactococcus lactis is a lactic acid bacterium commonly used in the dairy industry for fermentation and as a probiotic. Its use to support or treat autoimmune disorders is primarily based on emerging scientific evidence rather than tradition. Preclinical studies (mostly in animal models) have investigated genetically engineered L. lactis strains for their ability to deliver therapeutic molecules, such as interleukin-10 (IL-10), directly to the gut. IL-10 is an anti-inflammatory cytokine that can modulate immune responses and may be beneficial in autoimmune diseases such as inflammatory bowel disease (IBD) and type 1 diabetes.

For example, a landmark study published in Science (Steidler et al., 2000) demonstrated that oral administration of L. lactis engineered to secrete IL-10 reduced inflammation in a mouse model of colitis. Follow-up early-phase clinical trials have shown that this strategy is safe, but evidence of efficacy in humans remains limited and inconclusive. There is also some evidence that L. lactis may generally modulate the gut microbiome and immune system, potentially influencing autoimmune processes, but these effects are not yet robustly characterized in humans.

In summary, the use of Lactococcus lactis for autoimmune disorders is supported by preclinical and early clinical research, but high-quality evidence in humans is lacking. Its use is not based on tradition, and its efficacy for autoimmune disorders in clinical practice is not yet established.

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