Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactoferrin is a multifunctional glycoprotein most commonly found in milk and various mucosal secretions. Its immunomodulatory and anti-inflammatory properties have attracted scientific interest concerning its potential role in autoimmune disorders. Several preclinical studies demonstrate that lactoferrin can modulate immune responses, lower pro-inflammatory cytokine production (such as TNF-α and IL-6), and support the activity of regulatory T cells, which are critical in controlling autoimmune responses. Animal models of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis, have shown that lactoferrin administration can reduce disease severity and inflammation.

However, human clinical trials specifically evaluating lactoferrin supplementation in patients with diagnosed autoimmune diseases are limited and often small in scale. Some clinical studies have investigated its use in inflammatory bowel disease and have reported improvements in inflammatory markers and symptoms, but these results are preliminary. There is theoretical rationale for lactoferrin’s use, based on its regulation of immune homeostasis and gut barrier function, both relevant to autoimmunity. Yet, the lack of robust, large-scale, randomized controlled trials in human autoimmune populations limits the strength of the evidence.

In summary, while there is a scientific basis and promising preliminary evidence from cell and animal research, and some small human studies, the clinical efficacy of lactoferrin for autoimmune disorders is not yet well established. More rigorous human trials are needed to justify routine use in this context.

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Metagenics Probioplex® Intensive Care Powder