Evidence supporting the use of: Licorice root
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Licorice root (Glycyrrhiza glabra) has a long history of use in traditional medicine systems, such as Traditional Chinese Medicine (TCM) and Ayurveda, for a variety of health concerns, including inflammation and immune modulation. In TCM, licorice is often included in herbal formulas designed to harmonize and moderate the effects of other herbs, and it is sometimes prescribed for conditions with autoimmune features, such as rheumatoid arthritis or systemic lupus erythematosus, to help "clear heat" and "detoxify." However, the traditional rationale is based on empirical observations and the energetics of herbs rather than on modern biomedical understanding of autoimmunity. From a scientific perspective, there is some preliminary evidence that glycyrrhizin and other compounds in licorice root exhibit anti-inflammatory and immunomodulatory effects in vitro (test tube studies) and in animal models. These effects include suppression of pro-inflammatory cytokines and modulation of immune cell activity. However, robust clinical trials in humans with autoimmune diseases are lacking, and the available evidence is not strong enough to support its routine use for these conditions. Furthermore, licorice root can have significant side effects, especially with prolonged use, such as hypertension and hypokalemia. Thus, while traditional use exists and there are plausible mechanistic pathways, the current scientific evidence is limited and does not strongly validate its use for treating autoimmune disorders.

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Other health conditions supported by licorice root

Abdominal Pain
Abrasions
Abscesses
Acid Indigestion
Acne
Addictions (general remedies for)
Addictions (tobacco smoking or chewing)
Addison's Disease
Adenitis
Adrenal Fatigue
Afterbirth Pain
Age Spots
Allergies (respiratory)
Amenorrhea
Anal Fistula or Fissure
Anemia
Appetite (deficient)
Asthma
Autoimmune Disorders
Bronchitis
Canker Sores
Chemotherapy (reducing side effects)
Chicken Pox
Cholera
Chronic Obstructive Pulmonary Disorder
Cirrhosis of the Liver
Cold Sores
Colds (antiviral)
Colds (decongestant)
Colds (general)
Colds (prevention)
Colds (with fever)
Colic (adults)
Colic (children)
Colitis
Colon (atonic)
Colon (spastic)
Congestion
Congestion (bronchial)
Congestion (lungs)
Congestion (lymphatic)
Congestion (sinus)
Constipation (adults)
Contagious Diseases
Convalescence
Cough (damp)
Cough (dry)
Cough (general)
Cough (spastic)
Cramps (menstrual)
Crohn's Disease
Croup
Cushing's Disease
Cytomealovirus
Dyspepsia
Eczema
Emphysema
Endometriosis
Enteritis
Epstein Barr Virus
Estrogen (low)
Fatty Liver Disease
Fever
Fibrosis
Gall Bladder (sluggish or removed)
Gall Stones
Gas and Bloating
Gastritis
Gingivitis
Glands (swollen lymph)
Goiter
Gonorrhea
Gout
Grave's Disease
Hair (loss or thinning)
Hair Care (general)
Halitosis
Hangover
Headache (general)
Headache (sinus)
Headache (tension)
Heart (weakness)
Hemorrhoids
Hepatitis
Hernias
Herpes
Hiatal Hernia
Hiccups
Hot Flashes
Hypotension
Hypothyroid
Impetigo
Indigestion
Infection
Infection (bacterial)
Infection (viral)
Inflammation
Inflammatory Bowel Disorders
Influenza
Injuries
Itching
Itching Ears
Jaundice (adults)
Jock Itch
Kidney Infection
Laryngitis
Leaky Gut Syndrome
Leprosy
Lesions
Leucorrhea
Liver Detoxification
Lungs (fluid in)
Lyme Disease
Lymph Nodes or Glands (swollen)
Malaria
Mastitis
Measles
Menopause
Menorrhagia
Menstrual Irregularity
Menstruation (scant)
Mental Illness
Metabolic Syndrome
Mononucleosis
Mood Swings
Morning Sickness
Mumps
Nausea and Vomiting
Nephritis
Nervous Exhaustion
Nervousness
Night Sweating
Nocturnal Emission
Oral Surgery
Ovarian Pain
Overacidity
Pertussis
Pleurisy
PMS (general)
Pneumonia
Poison Ivy or Oak
Rashes and Hives
Rosacea
Sore Throat
Ulcers