Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Luteolin is a naturally occurring flavonoid found in various fruits, vegetables, and medicinal plants. Its use in supporting or treating autoimmune disorders is primarily grounded in preclinical scientific research rather than traditional medicine. Numerous laboratory (in vitro) and animal (in vivo) studies have suggested that luteolin possesses anti-inflammatory and immunomodulatory properties. For example, luteolin has been shown to inhibit the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, which are central to the pathogenesis of many autoimmune diseases. Additionally, luteolin can modulate signaling pathways involved in immune cell activation, such as the NF-κB and MAPK pathways. Some animal studies have demonstrated that luteolin can reduce symptoms in models of autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. These effects are attributed to its ability to suppress immune cell infiltration and decrease tissue inflammation. However, despite promising laboratory and animal evidence, clinical studies in humans are extremely limited. There is currently a lack of well-designed randomized controlled trials demonstrating that luteolin is safe and effective for treating autoimmune disorders in human patients. Most of the available evidence is preclinical, and more research is needed before luteolin can be recommended as a standard therapy. Therefore, while scientific interest and mechanistic plausibility exist, clinical validation is currently insufficient.

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