Evidence supporting the use of: Melatonin
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Melatonin, a hormone primarily produced by the pineal gland, is well known for its role in regulating sleep-wake cycles. Its use in autoimmune disorders is based on emerging scientific evidence rather than traditional use. Preclinical studies and some small clinical trials have explored melatonin’s immunomodulatory properties. Melatonin appears to influence both innate and adaptive immune responses, often exerting anti-inflammatory effects by reducing pro-inflammatory cytokines (such as TNF-α, IL-6) and increasing anti-inflammatory cytokines (like IL-10). Animal studies have shown that melatonin can ameliorate symptoms in models of multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus.

However, human studies are limited and results are mixed. Some small trials suggest potential benefits in reducing disease activity or improving sleep and quality of life in patients with autoimmune conditions, but the data are not robust or consistent. There are also concerns that, due to melatonin’s immune-enhancing properties, it could potentially exacerbate certain autoimmune conditions, depending on the underlying immune imbalance.

In summary, melatonin’s use in autoimmune disorders is supported by preclinical research and limited clinical data, but high-quality, large-scale human trials are lacking. Thus, its evidence rating is 2 out of 5. Patients should consult healthcare providers before using melatonin for autoimmune conditions, as effects may vary depending on the specific disorder and individual immune response.

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