Evidence supporting the use of: Mushrooms
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mushrooms, particularly medicinal varieties such as Reishi (Ganoderma lucidum), Shiitake (Lentinula edodes), Maitake (Grifola frondosa), and Turkey Tail (Trametes versicolor), have been investigated for their potential immunomodulatory effects. Scientific interest stems from the presence of bioactive compounds like beta-glucans, triterpenoids, and polysaccharide-K (PSK), which may influence immune function. Preclinical studies and limited clinical trials suggest that certain mushroom extracts can modulate immune responses, sometimes enhancing immune activity and at other times exerting anti-inflammatory effects. In laboratory studies, mushrooms have been shown to promote regulatory T cell activity and reduce inflammatory cytokine production, mechanisms that could theoretically benefit autoimmune conditions by restoring immune balance. However, human data are sparse and inconsistent. Most clinical studies have focused on cancer or infectious diseases, not autoimmune disorders directly. A few small pilot studies and case reports indicate potential benefit for conditions like rheumatoid arthritis or multiple sclerosis, but these are not robust enough to draw firm conclusions. Thus, while there is a scientific rationale and some early supportive evidence, the strength of clinical evidence remains low (rated 2/5), and mushrooms should not be considered a proven therapy for autoimmune disorders. More rigorous, larger-scale human trials are needed to clarify their role and safety in this context.

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