Evidence supporting the use of: Polysaccharide
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polysaccharides, particularly those derived from medicinal mushrooms (such as beta-glucans from Ganoderma lucidum or Coriolus versicolor) and certain plants (like aloe vera or astragalus), have been investigated for their potential immunomodulatory effects. Scientific studies, especially in vitro and animal models, suggest that some polysaccharides can modulate immune responses, potentially supporting immune balance rather than simply stimulating or suppressing immunity. This has led to interest in their possible role in autoimmune disorders, where immune system regulation is crucial. Some small human studies and case reports indicate possible benefits, but results are inconsistent, and high-quality clinical trials are limited.

Mechanistically, polysaccharides may act through pathways involving toll-like receptors and cytokine modulation, potentially reducing autoimmune-related inflammation or promoting regulatory immune responses. However, the evidence base remains preliminary—most clinical studies focus on adjunctive cancer therapy or immune support in infection, not specifically on autoimmune diseases. Thus, while there is a scientific rationale and some early evidence, it is not robust enough to warrant a high confidence rating for treating or supporting autoimmune disorders. More rigorous clinical trials are needed to determine efficacy, safety, and best practices for use in this context.

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Products containing Polysaccharide

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