Evidence supporting the use of: Polysaccharides
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polysaccharides, particularly those derived from medicinal mushrooms (such as beta-glucans from Cordyceps, Ganoderma lucidum (Reishi), and Lentinula edodes (Shiitake)), as well as from plants like aloe vera and seaweeds, have been investigated for their potential immunomodulatory effects in the context of autoimmune disorders. Scientific studies, mainly in vitro and in animal models, show that certain polysaccharides can modulate immune responses by affecting cytokine production, enhancing regulatory T-cell activity, and promoting a balanced Th1/Th2 response, which may, in theory, help manage inappropriate immune activation characteristic of autoimmune diseases.

However, robust clinical evidence in humans is limited. A few small-scale clinical trials and observational studies have suggested potential benefits, such as improved symptoms or markers of inflammation in conditions like rheumatoid arthritis and inflammatory bowel disease, but these findings are preliminary and often lack rigorous controls. The majority of the supportive evidence is preclinical, and systematic reviews generally conclude that while polysaccharides show promise as immunomodulators, their efficacy and safety in autoimmune conditions remain uncertain. As such, while there is a scientific rationale and some early evidence, the overall quality and quantity of evidence is modest, justifying a rating of 2 out of 5.

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Products containing polysaccharides

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