Relationship: Autoimmune Disorders and selenium

Evidence supporting the use of: Selenium
For the health condition: Autoimmune Disorders

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Source of validity: Scientific
Rating (out of 5): 3

Selenium is an essential trace element that plays a critical role in the function of the immune system and antioxidant defense. Its use in supporting autoimmune disorders, especially autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease, is based on a growing body of scientific evidence. Selenium is a component of selenoproteins, including glutathione peroxidases and thioredoxin reductases, which help reduce oxidative stress and modulate immune responses. Several clinical studies and meta-analyses suggest that selenium supplementation can reduce thyroid peroxidase antibody (TPOAb) levels in patients with Hashimoto's thyroiditis, indicating a potential benefit in lowering autoimmune activity. Additionally, selenium supplementation has been associated with improved well-being and a reduction in inflammatory markers in some patients with autoimmune thyroid disorders. However, the evidence is mixed and not universally conclusive. While some randomized controlled trials have demonstrated modest benefits, others show limited or no effect on clinical outcomes such as thyroid function or symptom improvement. The therapeutic benefit of selenium supplementation appears to be more pronounced in individuals with low baseline selenium status. Excessive selenium intake can be toxic, so supplementation should be approached with caution and ideally under medical supervision. Overall, current scientific evidence supports a role for selenium in the management of certain autoimmune disorders, particularly autoimmune thyroid diseases, but more research is needed to establish optimal dosing, duration, and long-term safety.

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Other ingredients used for Autoimmune Disorders

adrenal cortex
amino acids
ashwagandha
astragalus
bacillus subtilis
bifidobacterium infantis
bifidobacterium longum
bupleurum falcatum
cat's claw
colostrum
turmeric
curcumin
epigallocatechin gallate (EGCG)
gamma linolenic acid (GLA)
ginger
green lipped mussel
green tea
immunoglobin G
Indian tinospora
l-glutamine
l-glutathione
l-glycine
lactococcus lactis
lactoferrin
lentinula edodes mycelia
licorice root
luteolin
magnesium
melatonin
n-acetyl-cysteine (NAC)
omega-3 fatty acids
prebiotic blend (proprietary)
quercetin
resveratrol
selenium
shiitake mushroom
specialized pro-resolving mediators (SPMs)
turkey tail mushroom
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
whey protein
zinc
shen-chu
tylophora
tinospora cordifolia
herbal blend (proprietary)
AHCC
Andrographolide
Astragaloside
Aureobasidium pullulans
Astragalin
Black Seed
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Boswellia
Bacteria
Bifidobacteria
Bee venom
Cortisol
Curcuminoid
C-Phycocyanin
Clostridium butyricum
Cytokines
Cannabigerol
Dialyzable Leukocyte Extract
Dihomo-gamma-linolenic acid

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Evidence supporting the use of: Selenium
For the health condition: Autoimmune Disorders

Table of Contents

Synopsis

Other ingredients used for Autoimmune Disorders

Other health conditions supported by selenium

Products containing selenium

Health Concerns

Brands

Evidence supporting the use of: SeleniumFor the health condition: Autoimmune Disorders

Table of Contents

Synopsis

Other ingredients used for Autoimmune Disorders

Other health conditions supported by selenium

Products containing selenium

Evidence supporting the use of: Selenium
For the health condition: Autoimmune Disorders