Relationship: Autoimmune Disorders and selenium

Evidence supporting the use of: Selenium
For the health condition: Autoimmune Disorders

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Source of validity: Scientific
Rating (out of 5): 3

Selenium is an essential trace element that plays a critical role in the function of the immune system and antioxidant defense. Its use in supporting autoimmune disorders, especially autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease, is based on a growing body of scientific evidence. Selenium is a component of selenoproteins, including glutathione peroxidases and thioredoxin reductases, which help reduce oxidative stress and modulate immune responses. Several clinical studies and meta-analyses suggest that selenium supplementation can reduce thyroid peroxidase antibody (TPOAb) levels in patients with Hashimoto's thyroiditis, indicating a potential benefit in lowering autoimmune activity. Additionally, selenium supplementation has been associated with improved well-being and a reduction in inflammatory markers in some patients with autoimmune thyroid disorders. However, the evidence is mixed and not universally conclusive. While some randomized controlled trials have demonstrated modest benefits, others show limited or no effect on clinical outcomes such as thyroid function or symptom improvement. The therapeutic benefit of selenium supplementation appears to be more pronounced in individuals with low baseline selenium status. Excessive selenium intake can be toxic, so supplementation should be approached with caution and ideally under medical supervision. Overall, current scientific evidence supports a role for selenium in the management of certain autoimmune disorders, particularly autoimmune thyroid diseases, but more research is needed to establish optimal dosing, duration, and long-term safety.

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Other ingredients used for Autoimmune Disorders

adrenal cortex
AHCC
amino acids
andrographolide
ashwagandha
astragalin
astragaloside
astragalus
Aureobasidium pullulans
bacillus subtilis
bacteria
Baikal Skullcap
bee venom
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium infantis
Bifidobacterium longum
black seed
Boswellia
Boswellic Acid
bupleurum falcatum
C-phycocyanin
cannabigerol
cat's claw
Clostridium butyricum
colostrum
cortisol
curcumin
Curcuminoid
cytokines
dialyzable leukocyte extract
Dihomo-gamma-linolenic acid
epigallocatechin gallate (EGCG)
fatty acids
fucoidan
fumaric acid
fungus
galactooligosaccharides
gamma linolenic acid (GLA)
ginger
Globulins
Glutathione
Glycosphingolipids
Glycyrrhizin
green tea
green-lipped mussel
herbal blend (proprietary)
immunoglobin G
Immunoglobulin G
Indian tinospora
L-glutamine
L-glutathione
L-glycine
Lactobacillus johnsonii
Lactococcus lactis
Lactoferrin
Lentinula edodes mycelia
licorice root
luteolin
magnesium
Melatonin
Mushroom
N-acetyl-cysteine (NAC)
Oldenlandia diffusa
Oligosaccharides
omega-3 fatty acids
Peptides
Pokeweed
polysaccharides
prebiotic blend (proprietary)
quercetin
resveratrol
selenium
Selenocysteine
shen-chu
shiitake mushroom
specialized pro-resolving mediators (SPMs)
Stellaria dichotoma
Sulforaphane
Thymoquinone
Tinospora cordifolia
Triterpenes
Turkey tail mushroom
turmeric
Tylophora
Tylophorine
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
Whey protein
Withanolides
Zinc

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Evidence supporting the use of: Selenium
For the health condition: Autoimmune Disorders

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Synopsis

Other ingredients used for Autoimmune Disorders

Other health conditions supported by selenium

Products containing selenium

Health Concerns

Brands

Evidence supporting the use of: SeleniumFor the health condition: Autoimmune Disorders

Table of Contents

Synopsis

Other ingredients used for Autoimmune Disorders

Other health conditions supported by selenium

Products containing selenium

Evidence supporting the use of: Selenium
For the health condition: Autoimmune Disorders