Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Tylophora (Tylophora indica) has a history of traditional use in Ayurvedic and folk medicine, particularly in India, for a variety of conditions, including respiratory ailments and some autoimmune-related disorders. Its use for autoimmune disorders is primarily rooted in traditional practice rather than modern scientific validation. The plant is believed to possess immunomodulatory, anti-inflammatory, and antiallergic properties, which may explain its use in managing symptoms associated with autoimmune diseases such as rheumatoid arthritis and asthma (which can involve immune dysregulation).

Preclinical studies have identified several alkaloids in Tylophora, such as tylophorine, that have shown immunosuppressive and anti-inflammatory effects in animal models. For example, some studies demonstrated reduced inflammation and immune cell proliferation in rodents. However, robust clinical trials in humans are lacking, and the quality of existing evidence is low. Only a handful of small-scale or poorly controlled human studies have been conducted, mostly for asthma, and these generally show modest benefits with notable side effects, including nausea and vomiting.

In summary, while Tylophora has a tradition of use for immune-mediated disorders and some preliminary pharmacological rationale, the evidence supporting its efficacy for autoimmune disorders is limited and not sufficient for strong clinical recommendations. More rigorous clinical research is needed to determine its safety and effectiveness in this context.

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