Evidence supporting the use of: Vitamin C (mixed ascorbates)
For the health condition: Autoimmune Disorders

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbic acid and its mixed ascorbate forms) has been explored as a supportive treatment in autoimmune disorders due to its well-established antioxidant and immunomodulatory properties. The scientific rationale comes from the fact that vitamin C can modulate immune cell function, reduce oxidative stress, and support collagen synthesis, which are theoretically beneficial in the context of autoimmune diseases where inflammation and immune dysregulation are common. Some small clinical studies and animal models have suggested that vitamin C supplementation may help reduce disease severity or symptom flares in conditions such as rheumatoid arthritis and systemic lupus erythematosus. For example, vitamin C has been shown to decrease markers of inflammation and oxidative damage in certain autoimmune populations. However, the overall quality of evidence is low, consisting primarily of observational studies, small randomized trials, and mechanistic research, rather than large-scale, high-quality clinical trials. There is no conclusive evidence that vitamin C, including mixed ascorbates, can treat or significantly alter the course of autoimmune diseases. Most guidelines do not recommend vitamin C as a standard therapy for autoimmune disorders, but it may be used adjunctively for general health or to address deficiencies. Thus, while there is some scientific basis for its use, the strength of evidence supporting vitamin C specifically for autoimmune treatment is weak.

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