Relationship: Autoimmune Disorders and vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Autoimmune Disorders

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Source of validity: Scientific
Rating (out of 5): 3

Vitamin D3 (cholecalciferol) is increasingly used as an adjunct in the management of autoimmune disorders, backed by a growing body of scientific evidence. Vitamin D receptors are present on various immune cells, including T cells and dendritic cells, suggesting vitamin D’s immunomodulatory role. Research indicates that vitamin D3 influences both innate and adaptive immunity by modulating the activity and proliferation of immune cells, reducing the production of pro-inflammatory cytokines, and promoting the development of regulatory T cells, which help prevent autoimmune responses.

Multiple observational studies have reported lower serum vitamin D levels in patients with autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and type 1 diabetes, suggesting an association between deficiency and increased risk or severity of these conditions. Some randomized controlled trials have shown modest benefits of vitamin D supplementation in reducing disease activity or relapse rates, particularly in MS and RA, though results are variable and sometimes inconsistent. Meta-analyses generally support a potential benefit, but emphasize the need for larger, well-designed trials.

While vitamin D3 is not a primary treatment for autoimmune diseases, its low risk and potential for benefit have led to recommendations for supplementation, especially in patients with documented deficiency. Current clinical guidelines often suggest maintaining adequate vitamin D levels as part of comprehensive autoimmune disease management.

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Other ingredients used for Autoimmune Disorders

adrenal cortex
amino acids
ashwagandha
astragalus
bacillus subtilis
bifidobacterium infantis
bifidobacterium longum
bupleurum falcatum
cat's claw
colostrum
turmeric
curcumin
epigallocatechin gallate (EGCG)
gamma linolenic acid (GLA)
ginger
green lipped mussel
green tea
immunoglobin G
Indian tinospora
l-glutamine
l-glutathione
l-glycine
lactococcus lactis
lactoferrin
lentinula edodes mycelia
licorice root
luteolin
magnesium
melatonin
n-acetyl-cysteine (NAC)
omega-3 fatty acids
prebiotic blend (proprietary)
quercetin
resveratrol
selenium
shiitake mushroom
specialized pro-resolving mediators (SPMs)
turkey tail mushroom
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
whey protein
zinc
shen-chu
tylophora
tinospora cordifolia
herbal blend (proprietary)
AHCC
Andrographolide
Astragaloside
Aureobasidium pullulans
Astragalin
Black Seed
Bifidobacterium
Baikal Skullcap
Bifidobacterium adolescentis
Boswellic Acid
Boswellia
Bacteria
Bifidobacteria
Bee venom
Cortisol
Curcuminoid
C-Phycocyanin
Clostridium butyricum
Cytokines
Cannabigerol
Dialyzable Leukocyte Extract
Dihomo-gamma-linolenic acid

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Evidence supporting the use of: Vitamin D3
For the health condition: Autoimmune Disorders

Table of Contents

Synopsis

Other ingredients used for Autoimmune Disorders

Other health conditions supported by vitamin D3

Products containing vitamin D3

Health Concerns

Brands

Evidence supporting the use of: Vitamin D3For the health condition: Autoimmune Disorders

Table of Contents

Synopsis

Other ingredients used for Autoimmune Disorders

Other health conditions supported by vitamin D3

Products containing vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Autoimmune Disorders