Evidence supporting the use of: Polyphenols (various)
For the health condition: Benign Prostate Hyperplasia

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyphenols, a broad class of naturally occurring compounds found in plants (including flavonoids, phenolic acids, and stilbenes), have been studied for their potential benefits in benign prostatic hyperplasia (BPH). The scientific rationale for their use centers around their anti-inflammatory and antioxidant properties, as chronic inflammation and oxidative stress are believed to contribute to the pathogenesis of BPH. Some polyphenol-rich foods and extracts—such as green tea (epigallocatechin gallate), pomegranate, and saw palmetto—have been investigated in preclinical and limited clinical studies for their effects on prostate health. For example, small clinical trials with green tea polyphenols have shown modest improvements in lower urinary tract symptoms (LUTS) and reductions in prostate-specific antigen (PSA) levels in men with BPH. Similarly, pomegranate extract has demonstrated anti-inflammatory effects in laboratory models, though robust clinical evidence is lacking.

Despite these promising mechanisms, large-scale, high-quality clinical trials specifically evaluating polyphenols for BPH are limited. Most evidence to date is preliminary, with mixed results regarding efficacy. Thus, while the use of polyphenols for BPH is justified by some scientific evidence, the strength of this evidence is modest (rated 2 out of 5). Polyphenols are not a standard, guideline-endorsed therapy for BPH, but may be considered as complementary approaches pending further research.

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Products containing polyphenols (various)

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