Relationship: Bipolar Mood Disorder and DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Bipolar Mood Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid) is an omega-3 fatty acid that has been studied for its potential role in supporting mental health, including Bipolar Mood Disorder. The scientific rationale stems from epidemiological and clinical observations indicating that populations with higher intake of omega-3 fatty acids tend to have lower rates of mood disorders. Furthermore, DHA is a major structural component of neuronal membranes and is believed to influence neuroinflammation, neurotransmitter function, and neuroprotection, all of which are implicated in mood regulation.

Several small randomized controlled trials and meta-analyses have examined the effects of omega-3 supplementation (typically a combination of EPA and DHA) in bipolar disorder. Some studies have shown modest benefits, particularly for depressive symptoms in bipolar disorder, but not consistently for manic symptoms. Notably, most positive findings are attributed to EPA rather than DHA alone. The evidence for DHA specifically remains limited and inconsistent, with some studies finding little to no effect when DHA is used as a monotherapy or as the primary omega-3 in supplementation.

Based on current evidence, while there is a scientific rationale and some preliminary supportive data, the overall clinical benefit of DHA for bipolar disorder is unproven and not robust. Most guidelines do not recommend DHA as a standalone treatment, though omega-3s (especially those rich in EPA) may be considered as adjunctive therapy in some cases. More large-scale, high-quality studies are needed to clarify DHA’s specific role.

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Other ingredients used for Bipolar Mood Disorder

DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
fish oil
inositol
L-theanine
magnesium
Marine lipid
N-acetyl-cysteine (NAC)
omega-3 fatty acids
pregnenolone
gastrodia
thyroid substance
fatty acids

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Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Bipolar Mood Disorder

Table of Contents

Synopsis

Other ingredients used for Bipolar Mood Disorder

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: DHA (docosahexaenoic acid)For the health condition: Bipolar Mood Disorder

Table of Contents

Synopsis

Other ingredients used for Bipolar Mood Disorder

Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Evidence supporting the use of: DHA (docosahexaenoic acid)
For the health condition: Bipolar Mood Disorder