Evidence supporting the use of: SAM-e
For the health condition: Bipolar Mood Disorder

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

S-adenosylmethionine (SAM-e) is a compound found naturally in the body and has been studied as a supplement for various mood disorders, including depression and, to a much lesser extent, bipolar mood disorder. The primary scientific evidence relates to its use in treating depressive symptoms rather than the full range of bipolar symptoms. Several small clinical trials and open-label studies have suggested that SAM-e may have antidepressant effects, possibly by influencing neurotransmitter metabolism (such as serotonin and dopamine). However, robust, large-scale randomized controlled trials specifically investigating SAM-e in bipolar disorder are lacking.

Importantly, there is concern within the psychiatric community regarding the use of SAM-e in bipolar disorder due to its potential to induce mania or hypomania, particularly in individuals with bipolar I disorder. Case reports and some clinical observations have documented episodes of mania following SAM-e use. As a result, many guidelines caution against its use in this population, or at least recommend close monitoring if it is considered as an adjunctive treatment for bipolar depression.

In summary, while there is some scientific investigation into SAM-e for mood disorders, the evidence specifically supporting its use in bipolar disorder is limited and mixed, with significant safety concerns regarding mood destabilization. Therefore, the evidence is rated as 2 out of 5, reflecting preliminary support but insufficient validation for routine use in bipolar disorder.

More about SAM-e
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