Evidence supporting the use of: 5-methyltetrahydrofolate glucosamine
For the health condition: Birth Defects (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

5-methyltetrahydrofolate glucosamine (5-MTHF GlcN) is a bioactive, stable salt form of 5-methyltetrahydrofolate, the predominant form of folate found in circulation and the biologically active form utilized in cellular metabolism. Folate supplementation, particularly periconceptionally and during the first trimester, is scientifically validated to reduce the risk of neural tube defects (NTDs) such as spina bifida and anencephaly in newborns. The evidence base for folate’s role in NTD prevention is robust, supported by large randomized controlled trials, meta-analyses, and population-wide fortification studies. While most clinical studies use folic acid, 5-MTHF is considered an effective alternative, especially for individuals with genetic polymorphisms (such as MTHFR C677T) that impair conversion of folic acid to its active form. 5-MTHF provides the active methylated folate directly, bypassing this enzymatic block, ensuring adequate folate status and homocysteine regulation. Studies have shown that 5-MTHF is at least as effective as folic acid in raising folate levels and preventing NTDs. The glucosamine salt enhances stability and bioavailability for supplementation. Major guidelines (CDC, WHO) recommend periconceptional folate supplementation for birth defect prevention, and 5-MTHF is recognized as a suitable form. Thus, use of 5-MTHF glucosamine for prevention of birth defects is grounded in strong scientific evidence.

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