American Liverleaf (Hepatica americana), also known as liverwort, has a history of use in North American traditional medicine, especially among Native American tribes and early settlers. It was commonly used to address various ailments, including liver disorders and as a general tonic. In the context of bites and stings, there is some ethnobotanical evidence that parts of the plant were applied externally as poultices or washes to soothe irritation and inflammation caused by insect bites or minor wounds. However, such uses are documented mainly in herbal compendia and ethnobotanical records from the 19th and early 20th centuries and are based on traditional knowledge rather than controlled scientific studies.

There is currently no robust scientific evidence or clinical trials supporting the efficacy of American Liverleaf specifically for bites and stings. The phytochemical profile of the plant does include tannins and saponins, which might confer some astringent or anti-inflammatory effects, but these properties have not been systematically studied in the context of dermatological applications for bites and stings. Consequently, while its use is rooted in tradition, the evidence for its effectiveness remains weak and anecdotal, justifying a low evidence score.