Tolu Balsam, a resin obtained from the Myroxylon balsamum tree, has a long history of traditional use in folk medicine, predominantly in Central and South America. It has been applied topically for various skin ailments, including minor wounds, bites, and stings. Historical sources and ethnobotanical literature cite its use as a soothing agent, leveraging its mild antiseptic, anti-inflammatory, and aromatic properties. The rationale for its use in bites and stings is primarily based on its perceived ability to reduce irritation and possibly prevent superficial infection due to its benzyl cinnamate and benzyl benzoate content, compounds with known antimicrobial activity.

However, there is a lack of rigorous scientific studies evaluating the direct efficacy of Tolu Balsam for bites and stings. Modern clinical evidence is extremely limited or absent, and regulatory agencies generally do not recognize it as an approved treatment for such conditions. In fact, Tolu Balsam is a known contact allergen and can cause dermatitis in sensitive individuals, which further limits its suitability for widespread topical use. In summary, while Tolu Balsam has historical/traditional use for bites and stings, there is minimal scientific validation to support its effectiveness for this specific indication.