Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Methenamine (also known as hexamethylenetetramine) is a compound with established medical use, particularly in supporting urinary tract health. Its primary indication is as a urinary antiseptic for the prophylaxis of recurrent urinary tract infections (UTIs), which directly supports the bladder body system. Methenamine works by being metabolized into formaldehyde in acidic urine, which acts as a non-specific antibacterial agent. This mechanism has been validated in multiple clinical studies and is recognized in clinical guidelines for the prevention of recurrent UTIs, especially in situations where long-term antibiotic use is undesirable due to resistance concerns.

While methenamine is not effective for treating acute infections, it has demonstrated efficacy in reducing the frequency of UTI recurrences, including those that affect the bladder (cystitis). Several randomized controlled trials and systematic reviews have supported its use in this context. However, its effectiveness depends on maintaining an acidic urinary pH, which sometimes requires adjunctive therapy (e.g., ascorbic acid) to acidify the urine. Methenamine is generally well-tolerated, but its use is contraindicated in patients with impaired renal or hepatic function.

Overall, the use of methenamine to support the bladder body system is scientifically substantiated, specifically for the long-term prevention of recurrent urinary tract and bladder infections, with a moderate to strong evidence base.

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Thorne Women's Daily Probiotic