Squaw Vine (Mitchella repens) has a long history of use in traditional herbal medicine, particularly among Native American and early North American settler communities. While it is most commonly associated with women's reproductive health—especially as a uterine tonic to support pregnancy and childbirth—there are some historical references to its use for urinary tract conditions as well.

The reasoning for its use in supporting the bladder body system is primarily grounded in folklore and traditional herbalism. Some herbalists included Squaw Vine in formulas for urinary tract health, likely due to its gentle astringent and anti-inflammatory properties. However, these uses are anecdotal, and there is no robust or well-documented scientific evidence to confirm its effectiveness for bladder health. Modern herbal texts occasionally mention Squaw Vine as a mild diuretic or urinary tonic, but these references are uncommon and generally not substantiated by clinical studies.

In summary, the use of Squaw Vine for bladder support is justified mainly by tradition, with only weak or indirect historical evidence and no scientific validation. The evidence for its effectiveness in this context is very limited.