Stone Root (Collinsonia canadensis) has a long history of use in traditional herbal medicine, particularly among Native American and 19th-century eclectic physicians. It was commonly employed as a remedy for various urinary and bladder complaints, such as irritation, inflammation, and urinary tract difficulties. Traditional herbalists believed Stone Root acted as a tonic and astringent for the genitourinary system, helping to strengthen and tone the tissues of the bladder and urinary tract. It was often recommended for issues such as cystitis, urinary frequency, and even for hemorrhoids (due to its purported effects on venous tone).

However, there is a lack of robust scientific research validating these uses. Modern pharmacological studies on Stone Root are limited, and there is little clinical evidence to confirm its efficacy or safety for bladder support. The active constituents, such as saponins, tannins, and volatile oils, have not been extensively studied for their effects on the urinary system. Most references to its use for bladder support come from historical texts and traditional herbal materia medica rather than contemporary clinical trials or laboratory research.

In summary, Stone Root's use to support the bladder is grounded primarily in traditional herbal practice, with limited to no scientific validation currently available.